Which actors/actresses would you cast as Bond villains?

I would pick as a Bond villain (the main baddie running a global crime syndicate) an actor whose main image with the public is normally as a sympathetic, well-liked person who plays similar characters (even if they may have a villain or dodgy character or two on their resume). I'm thinking names like:

Tom Hanks
Helen Mirren
Patrick Stewart
Meryl Streep
Kevin Costner
William Shatner
Jessica Chastain (she's been playing a lot of Take Charge Women lately)
George Clooney
Halle Berry
Jeff Bridges
Bryan Cranston