[CLOSED]

13 TV series where the leading role was replaced with another actor/actress.

01. Criminal Minds -- Mandy Patinkin left the show at start of season 3. Replaced by Joe Mantegna
02. Mission Impossible -- Steven Hill left, replaced by Peter Graves
03. The X-Files -- David Duchovny replaced with Robert Patrick
04. Doctor Who -- William Hartnell replaced with Patrick Troughton replaced with Jon Pertwee replaced with Tom Baker replaced with Peter Davison replaced with Colin Baker replaced with Sylvester McCoy...and in the revival Christopher Eccleston replaced with David Tennant replaced with Matt Smith replaced with Peter Capaldi
05. Head of the Class - Howard Hessemann was replaced with Billy Connolly.
06. Mystery Science Theater 3000 - Mike Nelson replaces Joel Hodgson on the Satellite of Love
07. The Hogan Family - Valerie Harper replaced with Sandy Duncan.
08. CSI - William Petersen replaced with Laurence Fishburne and later Ted Danson
09. Cheers - Shelley Long replaced with Kirstie Alley
10. Alias Smith & Jones - Pete Duel replaced with Roger Davis