Will the MCU last another 10 years?

Of course it is likely it will be around another 10 years! As for spider-woman she will be appearing in the next Spider-Man sequel by being introduce as Jessica Drew who is a MI6 agent or so the story goes, will see.

People sang this tune at the five-year mark. "Who will see a movie about Dr. Strange or Black Panther? Fans know these characters, but general audiences don't!" I'm sure we'll hear this all again at the fifteen and twenty-year mark.

The question is not whether or not the MCU will last another ten years; it's how will those ten years play out. Will they continue to enjoy box office success or will genuine genre fatigue and competitors with more compelling offerings begin to erode their dominance?

You are assuming that the Avengers -- in their current incarnation -- will remain the cornerstone of the MCU. Marvel has several other properties to choose from for new movies and television shows. They don't have to rely on "main characters" like most other franchises.

They will inevitably get Fantastic Four and X-Men back - even if Comcast wins the bid for Fox. The corporation that holds that IP (and is not Disney) will bear witness to fan backlash so profound and crippling that it will force their hand. It will make the current Star Wars backlash look like child's play. They will all cut deals to either sell or be Marvel produced. The longer it takes, the more anticipation will build for seeing the MCU treatments of those fabled characters.

Loyal fans don't care who holds the IP - as long as it's all in one place. We will have what every fandoms enjoys as its birthright - one shared universe, under Stan, with mutants and cosmic entities for all. Hee hee hee...

#MMM

I don't believe the MCU will maintain the same level of appeal if too many of the original characters die/leave/get fucked with.

One bomb won't kill off the MCU. If and when the MCU begins to decline, I feel as though their demise will be long and tortuous. Apathy takes it's time.

Doctor Strange and Ant-man may not have been household names but pretty much any comic fan knows of them.

To answer the threads question....maybe? The age thing is a factor, I expect Captain America and Iron Man will be done after Avengers 4 and they're the two most popular characters.

Thor, Hulk, Black Widow and Hawkeye will surely pack it in within the next 10 years. Only of them even has his own movies.

Don't know if Black Panther, Doctor Strange and Ant-man will keep going because they'll all be in the fifties. Guardians of the Galaxy might keep going if they change the team up like Avengers.

It depends what new properties they can introduce to offset any loss. If they got their hands on Fantastic Four and X-men they'd be just fine.

If they don't then I'm not sure who else they could have. They've practically done all the main characters at this point.

Or Black Panther for that matter.

Outside of the fan favorite actors of the MCU, there really is no such thing as main characters. Marvel makes obscure characters into main characters.

Only if they hire somebody like you for Kevin Feige's position or hand it over to Heather Antos, otherwise they'll be around for a long, long time. 

No but it also won't feel sad either.

Unpopular take: I think the success of Doctor Strange, Ant-Man, etc, is in part due to their attachment on the current Thanos macro arc train if you will. They're fully welcomed alongside Iron Man, Captain America, Thor, Hulk... so I think audiences want them to succeed to be credible peers.  The worst MCU films I think have been Thor & Thor 2, & Thor is one of the lead heroes of IW so his standalone malaise meant very little damage.

That Thanos ride ends in 2019. I hope there are seeds for a new engaging macro arc to be planted as early as 2020. Otherwise it's just throwing cards in the air.
X-Men &/or Fantastic Four injection would certainly help, to keep known legacy heroes alongside popular Black Panther, Captain Marvel, & of course Spider-Man.

It'll be both easy & expected that the MCU keep trying to mirror realistic geopolitical fervor, to remain timely.  More Stark-Rogers type conflicts of interest would also serve everyone well.  The age of infallible heroes is well gone.

I would compare it to star wars. Even if the quality does fall apart, it will still make enough money to turn profits. So, yes, of course it will be around in 10 years. The only question is will it still be the dominate force at the box office.