Post by dividavi on Jul 26, 2017 5:54:10 GMT
Sperm counts of Western men plummeting, analysis finds
By Susan Scutti, CNN
Updated 2257 GMT (0657 HKT) July 25, 2017
• Scientists analyzed 185 studies which included more than 42,000 men
• No significant declines were seen in sperm counts of men living in South America, Asia and Africa
(CNN)Sperm counts of men in North America, Europe, Australia and New Zealand are plunging, according to a new analysis published Tuesday.
Among these men there has been a 52% decline in sperm concentration and a 59% decline in total sperm count over a nearly 40-year period ending in 2011, the analysis, published in the journal Human Reproduction Update, said.
Scientists determine sperm count by looking at a sample of ejaculate under a microscope. For sperm concentration, they measure how many millions of sperm there are in each milliliter of fluid. Sperm count, then, is sperm concentration multiplied by the total volume of an ejaculate.
Researchers led by Dr. Hagai Levine of Hebrew University of Jerusalem examined thousands of studies and then conducted a meta-analysis of 185 studies. These included 42,935 male participants who provided semen samples between 1973 and 2011. The chosen studies were well distributed over the nearly 40 years of the study period and among 50 different countries. The analysis included information on fertility status, age, ejaculation abstinence time, semen collection method, sperm count method and geographic location at the level of continent.
Based on their analysis, the international team of researchers from Brazil, Denmark, Israel, Spain and the United States reported a decline in sperm concentration of 1.4% per year with an overall drop of 52.4% during the entire study period for men living in industrialized, Western countries. Meanwhile, total sperm count among the same group plunged 1.6% per year and 59.3% overall. By comparison, the researchers found no significant declines in the sperm counts and sperm concentrations of men living in South America, Asia and Africa.
"The extent of the decline is a heartache," said Levine. "It's hard to believe -- it's hard to believe for me."
The high proportion of men in Western countries with sperm concentrations below 40 million/ml is "particularly concerning," wrote Levine and his co-researchers, because evidence indicates that a sperm concentration below this threshold is associated with a "decreased monthly probability of conception."
Past studies on sperm quality
Levine noted that his study follows in the footsteps "a seminal paper published in 1992" known as the Carlsen study. In that meta-analysis of 61 studies worldwide, researchers led by Elisabeth Carlsen, a Danish reproductive biologist, found a trend toward decreasing sperm count and volume of seminal fluid over a 50-year period ending in 1991.
Many people did not accept the results of the study, said Levine, "it was quite controversial whether or not there is a decline." However, Levine noted, "there were serious limitations to the [Carlsen] study." For example, a common criticism of the Carlsen group is that it included one overly large study -- it contributed 30% of the total participants, thus heavily influenced the results. By comparison, the largest of the studies examined by Levine's group included only 5% of all participants.
Since 1992, other researchers conducted analyses to understand whether sperm counts have declined, yet the results were mixed.
"Now we have a pretty solid answer," said Levine, who said his own study performed a meta-regression, "a more conservative, sophisticated analysis," one that accounts for factors that might influence the results.
Though Levine emphasized that his analysis did not study the cause of declines, he speculated the reason may be "we are exposed to many chemicals we've never been exposed to before."
Previous studies, including his own, show that exposure in utero to endocrine disrupting chemicals can harm male reproductive system development and fertility potential. Commonly used chemicals, including pesticides, lead and fire retardants, can increase or decrease production of certain hormones within our bodies and so are said to disrupt our endocrine, or hormone-making, system.
Sonya Lunder, a senior analyst at the nonprofit advocacy group Environmental Working Group, noted that sperm is manufactured daily by men's bodies. Recent exposures to environmental chemicals would have an effect on sperm, which serves as a good indicator of contamination, while also serving as a good biomarker of men's health.
Lunder cites the work of Russ Hauser, a professor of reproductive physiology at Harvard T.H. Chan School of Public Health, who suggests that exposure to endocrine-disrupting chemicalsmay be associated with poorer sperm quality among men and worse reproductive outcomes among women.
Still, Lunder noted, "there's not one route to reduction in sperm quality and sperm count for men. By all accounts, people assume there are multiple factors at work."
More explanations: obesity, climate change
Michael Dourson, a professor in the Risk Science Center at the University of Cincinnati College of Medicine, said in an email that "the overall work appears to be solid with numerous safeguards for assuring systematic review and data analysis." Dourson, who was not involved in the research, added, "the observed trends appear to be real, and not based on chance findings."
Yet, Dourson noted that he wondered about the "functional significance of the findings." The authors wrote that "poor sperm count is associated with overall morbidity and mortality," yet Dourson noted that "longevity is increasing" in Western countries so "these two observations do not appear to match."
"I suspect that obesity may have something to do with these trends, but measures of obesity, such as BMI (body mass-index) were not analyzed," said Dourson, who was recently nominated to head the US Environmental Protection Agency's Office of Chemical Safety and Pollution Prevention. "Overall, however, a request for funding for further exploration seems well founded."
Dr. Harry Fisch, a clinical professor of urology at Weill Cornell Medicine, said the results of this study are likely to be "real." Fisch, who has also researched this topic -- though he was not involved in the current analysis -- noted that one issue with all studies is the fact that sperm counting methodologies have not been standardized across the globe or even within most countries.
Another very important consideration is how geography influences sperm count. "Even within the US, different states have different counts," said Fisch, though all states fall within the range of normal. Fisch observed that the new analysis did not delve into differences among countries.
The only environmental factor that's "not controversial" and "known to influence sperm counts is temperature change," said Fisch, who noted that sperm counts are known to vary by season and by climate. "I think global warming, not phthalates, is responsible" for the declining rates seen here, he said. Phthalates, found in everything from flooring to personal care products, are one type of endocrine disrupting chemical.
Kathryn St. John, senior director of strategic communications for the American Chemistry Council, noted this meta-analysis, though a systematic review, is a study of other studies.
"The original studies did not account for fundamental and important information about lifestyles and health status of participants, so such factors cannot be accounted for in the overall results," said St. John, who noted that sperm count is just one measure of male health. "As to the overall state of men's health, it should be noted that life expectancy for men in the US has increased by 25 years over the past 100," St. John said.
But each scientist and representative agreed: Questions around sperm quality warrant continued research.
"The impact of the modern environment on health of populations and individuals is clearly huge, but remains largely unknown," said Levine. "Sperm count has previously been plausibly associated with environmental and lifestyle influences, including prenatal chemical exposure, adult pesticide exposure, smoking, stress and obesity. Every man can reduce exposure to chemicals, avoid smoking, keep balanced diet and weight and reduce stress."
By Susan Scutti, CNN
Updated 2257 GMT (0657 HKT) July 25, 2017
• Scientists analyzed 185 studies which included more than 42,000 men
• No significant declines were seen in sperm counts of men living in South America, Asia and Africa
(CNN)Sperm counts of men in North America, Europe, Australia and New Zealand are plunging, according to a new analysis published Tuesday.
Among these men there has been a 52% decline in sperm concentration and a 59% decline in total sperm count over a nearly 40-year period ending in 2011, the analysis, published in the journal Human Reproduction Update, said.
Scientists determine sperm count by looking at a sample of ejaculate under a microscope. For sperm concentration, they measure how many millions of sperm there are in each milliliter of fluid. Sperm count, then, is sperm concentration multiplied by the total volume of an ejaculate.
Researchers led by Dr. Hagai Levine of Hebrew University of Jerusalem examined thousands of studies and then conducted a meta-analysis of 185 studies. These included 42,935 male participants who provided semen samples between 1973 and 2011. The chosen studies were well distributed over the nearly 40 years of the study period and among 50 different countries. The analysis included information on fertility status, age, ejaculation abstinence time, semen collection method, sperm count method and geographic location at the level of continent.
Based on their analysis, the international team of researchers from Brazil, Denmark, Israel, Spain and the United States reported a decline in sperm concentration of 1.4% per year with an overall drop of 52.4% during the entire study period for men living in industrialized, Western countries. Meanwhile, total sperm count among the same group plunged 1.6% per year and 59.3% overall. By comparison, the researchers found no significant declines in the sperm counts and sperm concentrations of men living in South America, Asia and Africa.
"The extent of the decline is a heartache," said Levine. "It's hard to believe -- it's hard to believe for me."
The high proportion of men in Western countries with sperm concentrations below 40 million/ml is "particularly concerning," wrote Levine and his co-researchers, because evidence indicates that a sperm concentration below this threshold is associated with a "decreased monthly probability of conception."
Past studies on sperm quality
Levine noted that his study follows in the footsteps "a seminal paper published in 1992" known as the Carlsen study. In that meta-analysis of 61 studies worldwide, researchers led by Elisabeth Carlsen, a Danish reproductive biologist, found a trend toward decreasing sperm count and volume of seminal fluid over a 50-year period ending in 1991.
Many people did not accept the results of the study, said Levine, "it was quite controversial whether or not there is a decline." However, Levine noted, "there were serious limitations to the [Carlsen] study." For example, a common criticism of the Carlsen group is that it included one overly large study -- it contributed 30% of the total participants, thus heavily influenced the results. By comparison, the largest of the studies examined by Levine's group included only 5% of all participants.
Since 1992, other researchers conducted analyses to understand whether sperm counts have declined, yet the results were mixed.
"Now we have a pretty solid answer," said Levine, who said his own study performed a meta-regression, "a more conservative, sophisticated analysis," one that accounts for factors that might influence the results.
Though Levine emphasized that his analysis did not study the cause of declines, he speculated the reason may be "we are exposed to many chemicals we've never been exposed to before."
Previous studies, including his own, show that exposure in utero to endocrine disrupting chemicals can harm male reproductive system development and fertility potential. Commonly used chemicals, including pesticides, lead and fire retardants, can increase or decrease production of certain hormones within our bodies and so are said to disrupt our endocrine, or hormone-making, system.
Sonya Lunder, a senior analyst at the nonprofit advocacy group Environmental Working Group, noted that sperm is manufactured daily by men's bodies. Recent exposures to environmental chemicals would have an effect on sperm, which serves as a good indicator of contamination, while also serving as a good biomarker of men's health.
Lunder cites the work of Russ Hauser, a professor of reproductive physiology at Harvard T.H. Chan School of Public Health, who suggests that exposure to endocrine-disrupting chemicalsmay be associated with poorer sperm quality among men and worse reproductive outcomes among women.
Still, Lunder noted, "there's not one route to reduction in sperm quality and sperm count for men. By all accounts, people assume there are multiple factors at work."
More explanations: obesity, climate change
Michael Dourson, a professor in the Risk Science Center at the University of Cincinnati College of Medicine, said in an email that "the overall work appears to be solid with numerous safeguards for assuring systematic review and data analysis." Dourson, who was not involved in the research, added, "the observed trends appear to be real, and not based on chance findings."
Yet, Dourson noted that he wondered about the "functional significance of the findings." The authors wrote that "poor sperm count is associated with overall morbidity and mortality," yet Dourson noted that "longevity is increasing" in Western countries so "these two observations do not appear to match."
"I suspect that obesity may have something to do with these trends, but measures of obesity, such as BMI (body mass-index) were not analyzed," said Dourson, who was recently nominated to head the US Environmental Protection Agency's Office of Chemical Safety and Pollution Prevention. "Overall, however, a request for funding for further exploration seems well founded."
Dr. Harry Fisch, a clinical professor of urology at Weill Cornell Medicine, said the results of this study are likely to be "real." Fisch, who has also researched this topic -- though he was not involved in the current analysis -- noted that one issue with all studies is the fact that sperm counting methodologies have not been standardized across the globe or even within most countries.
Another very important consideration is how geography influences sperm count. "Even within the US, different states have different counts," said Fisch, though all states fall within the range of normal. Fisch observed that the new analysis did not delve into differences among countries.
The only environmental factor that's "not controversial" and "known to influence sperm counts is temperature change," said Fisch, who noted that sperm counts are known to vary by season and by climate. "I think global warming, not phthalates, is responsible" for the declining rates seen here, he said. Phthalates, found in everything from flooring to personal care products, are one type of endocrine disrupting chemical.
Kathryn St. John, senior director of strategic communications for the American Chemistry Council, noted this meta-analysis, though a systematic review, is a study of other studies.
"The original studies did not account for fundamental and important information about lifestyles and health status of participants, so such factors cannot be accounted for in the overall results," said St. John, who noted that sperm count is just one measure of male health. "As to the overall state of men's health, it should be noted that life expectancy for men in the US has increased by 25 years over the past 100," St. John said.
But each scientist and representative agreed: Questions around sperm quality warrant continued research.
"The impact of the modern environment on health of populations and individuals is clearly huge, but remains largely unknown," said Levine. "Sperm count has previously been plausibly associated with environmental and lifestyle influences, including prenatal chemical exposure, adult pesticide exposure, smoking, stress and obesity. Every man can reduce exposure to chemicals, avoid smoking, keep balanced diet and weight and reduce stress."
